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fentanyl, cyproheptadine. Both increases toxicity in the other by pharmacodynamic synergism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with anticholinergics may enhance risk for urinary retention and/or intense constipation, which may bring about paralytic ileus.If coadministration of CYP3A4 inhibitors with fentanyl is necessar